Jenny's battle with Alzheimer's Disease
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Sarek asks
Have you asked your doctor about Nicotinamide Riboside? Study in PNAS last week showed supplementation with nicotinamide riboside has potential for Alzheimer's. Google It.
"Alzheimer’s disease (AD) is the most common form of dementia, and there is no cure. DNA repair activity is deficient in AD patient brains, especially DNA polymerase β (Polβ), a key protein in DNA base excision. NAD+ is a cellular metabolite critical for mitochondrial health and biogenesis, stem cell self-renewal, and neuronal stress resistance. This study shows that NAD+ levels were decreased in a new AD mouse model with introduced DNA repair deficiency (3xTgAD/Polβ+/−), and NAD+ supplementation with nicotinamide riboside significantly normalized neuroinflammation, synaptic transmission, phosphorylated Tau, and DNA damage as well as improved learning and memory and motor function. This has implications for human AD intervention."
You can buy NR online right now for about $60 a month. Ask your doctor their opinion.
Best of luck.
Jenny's battle with Alzheimers Disease
Thanks for your support, we have known of Mark Mattson's work over many years. His area is oxidative stress, which has been studied for quite some time in connection with cellular ageing and DNA damage and repair. There's been a whole literature about antioxidants like vitamin C, vitamin E, red wine etc as protection against aspects of ageing, with flow-on to age-related diseases such as Alzheimer's disease and Parkinson's disease. NAD is a substrate in that biochemical pathway.
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